We sought to compare post-discharge adherence patterns with two common venous thromboembolism chemoprophylaxis regimens (low molecular weight heparin and aspirin) after orthopedic trauma and to identify risk factors for nonadherence.
Pulmonary embolism (PE) is one of the most common causes of death in trauma patients who survive beyond the first 24 hours after injury, and orthopedic trauma patient are at particularly high risk for venous thromboembolism (VTE). As a result, many trauma patients with orthopedic injuries are treated with chemoprophylaxis after discharge from their index admission. Nonadherence with chemoprophylaxis is known to be significantly associated with increased VTE risk. Unfortunately there is little quality data describing post-discharge adherence with the most common chemoprophylaxis regimens (low molecular weight heparin and aspirin) in this population. We conducted a randomized controlled trial in which we examined post-discharge adherence in this population, comparing adherence with these two regimens and identifying risk factors for nonadherence.
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