The aim of the present review was to compare the perioperative outcomes of acute laparoscopic versus open repair for peptic ulcer disease.
Surgery is the treatment of choice for perforated peptic ulcer disease. Feasibility of this approach has been demonstrated in several retrospective series over the past few decades, with institutional preferences determining which approach has been used. A selective approach is obvious in noncontrolled observational studies. Previous systematic reviews are largely based on retrospective case series with few randomized controlled trials (RCTs). Recently, further RCTs have been published comparing laparoscopic repair versus open repair of PPU. A systematic literature search was performed for randomized controlled trials (RCTs) published in PubMed, SCOPUS, andWeb of Science. The search included eight RCTs: 615 patients comparing laparoscopic (307 patients) versus open peptic perforated ulcer repair (308 patients).
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